GLP-1 Dosing Guide

This guide explains the standard dosing protocol for GLP-1 medications.

1

Initiation phase (first 4 weeks)

Semaglutide:

0.25 mg subcutaneous once weekly.

Tirzepatide:

2.5 mg subcutaneous once weekly.

These starter doses mainly condition the gut and rarely deliver full glucose or weight benefits.

2

Titration (dose escalation)

After week 4 the dose usually rises to the first "therapeutic" level—0.5 mg for semaglutide, 5 mg for tirzepatide. Further increases are made in 4-week steps if the patient tolerates the current dose and still needs stronger effect.

3

Maximum Labeled Doses:

Semaglutide for diabetes (Ozempic®)

— up to 2 mg weekly.

Semaglutide for weight management (Wegovy®)

— up to 2.4 mg weekly.

Tirzepatide (Mounjaro®)

— up to 15 mg weekly.

Not every patient needs—or can tolerate—these ceiling doses.

4

Adjusting for side effects

If troublesome symptoms appear during titration, a clinician may hold the dose longer or step it back until side effects settle.

Using the Stepper Component

You can also use the Stepper component directly in your MDX files:

1

Install the medication

Remove the pen from the refrigerator and let it warm to room temperature for 30 minutes.

2

Prepare the injection site

Choose an area on your abdomen, thigh, or upper arm. Clean with an alcohol swab and let dry.

3

Administer the injection

Follow the specific instructions for your pen device. Insert the needle and press the button to deliver the dose.

4

Dispose of the needle

Safely dispose of the used needle in a sharps container.